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NBTS Brain Tumor Clinical Trials Report: Q3 2020

It can be hard for patients and care partners to keep track of new clinical trial opportunities opening across the country, especially during the current public health crisis created by the coronavirus (COVID-19). However, there are many brain tumor clinical trials still actively enrolling patients, and this report provides a summary of the studies that have recently opened or started. To learn more about each trial, and contact the party responsible for enrolling patients, just follow the link provided under the brief description of each listing.


  • CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children
    • Brief Description: This phase I trial investigates the side effects of chemotherapy and cellular immunotherapy in treating children with IL13Ralpha2 positive brain tumors that have come back after a period of improvement (recurrent) or do not respond to treatment (refractory).
    • LINK
  • Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial
    • Brief Description: This phase II pediatric MATCH trial studies how well selpercatinib works in treating pediatric patients with solid tumors, including some brain tumor types like ependymoma, malignant glioma (grades II-IV), PNET, rhabdoid tumor, and medulloblastoma.
    • LINK
  • Phase I Study of Marizomib + Panobinostat for Children With DIPG (DIPG)
    • Brief Description: This phase I trial is evaluating the safety, tolerability and preliminary efficacy of the drugs marizomib and panobinostat in pediatric patients with diffuse intrinsic pontine glioma (DIPG).
    • LINK
  • Mycophenolate Mofetil Combined With Radiation Therapy in Recurrent Glioblastoma
    • Brief Description: This is a phase 0/I dose-escalation trial to determine the maximum tolerated dose of the drug Mycophenolate Mofetil (MMF) when administered with radiation, in patients with recurrent glioblastoma or recurrent gliosarcoma.
    • LINK
  • VB-111 in Surgically Accessible Recurrent/Progressive GBM
    • Brief Description: This phase II trial is studying a new viral cancer therapy, ofranergene obadenovec (VB-111), for recurrent or progressive glioblastoma (GBM), a brain tumor that is growing or progressing despite earlier treatment.
    • LINK
  • DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab (DERIVe)
    • Brief Description: This phase II trial is trying to determine if the study vaccine, called pp65 CMV dendritic cells, can trigger your immune system to fight off the tumor cells in your brain.
    • LINK
  • Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma
    • Brief Description: This phase II/III trial compares the usual treatment with radiation therapy and temozolomide to radiation therapy plus immunotherapy with ipilimumab and nivolumab in treating patients with newly diagnosed MGMT unmethylated glioblastoma.
    • LINK
  • Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 Mutations
    • Brief Description: This phase I trial will evaluate the safety, tolerability, and preliminary efficacy of oral administration of the drug LY3410738 in patients with IDH1 R132-mutant advanced solid tumor types, including gliomas.
    • LINK
  • Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma
    • Brief Description: This phase I trial studies how well serial magnetic resonance (MR) imaging and MR spectroscopic imaging work in characterizing low-grade glioma. Diagnostic procedures, such as MR imaging and MR spectroscopic imaging, may detect serial changes in low-grade glioma. This study may help researchers learn more about practical ways of evaluating and standardizing treatment in patients with brain tumors.
    • LINK

For a more comprehensive list of ALL open brain tumor clinical trials, please visit the NBTS Clinical Trial Finder at trials.braintumor.org, where you can search potential opportunities for enrollment based on criteria important and specific to you.

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