Below is a list of phase III clinical trials that are currently open for primary brain tumor patients in the United States.
A phase III clinical trial is traditionally the last, pivotal step in the evaluation of a potential new medicine before it is approved for use by all patients with the indicated disease.
Many of these are trials of a “novel/investigational agent” – meaning it is the first time a particular treatment is being tried for brain tumor patients. There are also a number of trials with therapies already in use for some brain tumor patients, which researchers are evaluating in different combinations, different dosing regimens, and/or specific subgroups of patients.
Phase III Clinical Trials with Novel/Investigational Agents
- An Investigation Immune-Therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo for Newly Diagnosed GBM Patients (CheckMate548)
- The immunotherapy drug nivolumab (Opdivo) is also being studied in patients with newly diagnosed MGMT-methylated GBM in combination with radiation and temozolomide.
- Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients
- The purpose of this study is to compare the effectiveness and safety of the drug eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy. Known as the STELLAR Study.
- Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery
- The purpose of this study is to evaluate how well tozuleristide, when used with the Canvas imaging systems, works at helping to distinguish between tumor and normal tissue during surgery in pediatric primary central nervous system tumors.
Phase III Clinical Trials with Prior/Known Agents
- A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low-Grade Glioma
- This study is trying to learn and understand if the chemotherapy drug called carboplatin works as well as alone for children and young adults with low-grade glioma (LGG) as the current standard of care: a combination of carboplatin and vincristine. Additionally, this study will try to understand if treatment with carboplatin alone is associated with an improved quality of life for LGG patients and their families.
- Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low-Grade Glioma
- This study seeks to determine whether radiation in combination with temozolomide — or radiation in combination with the chemotherapy PCV — is more effective in treating anaplastic glioma or LGG.
- Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma
- This partially randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma.
- Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO-II)
- This study tests if the median progression-free survival (PFS) of patients with newly diagnosed glioblastoma (GBM) can be improved by the addition of intraoperative radiotherapy (IORT) to standard radiochemotherapy.
- Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma (CSCRGBM)
- This study is designed to determine if recurrent glioblastoma (GBM) patients treated with FDA-approved drugs predicted by the ChemoID test will have better outcomes than patients treated with standard-of-care control therapy chosen by the physician (chemotherapy chosen by the Physician from a provided list).
- Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
- This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery.
For a more comprehensive list of ALL open brain tumor clinical trials, please visit the NBTS Clinical Trial Finder at trials.braintumor.org, where you can search potential opportunities for enrollment based on criteria important and specific to you.